Genetic Organization of Open Chromatin Domains Situated in Polytene Chromosome Interbands in Drosophila

New data on the organization of genes entirely located in the open domains for chromatin transcription and occupying only one chromosome structure (interband) were obtained. The characteristic features of these genes are the small size (on average, 1–2 kb), depletion of the replicative complex prote...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2018-11, Vol.483 (1), p.297-301
Main Authors: Zykova, T. Yu, Popova, O. O., Khoroshko, V. A., Levitsky, V. G., Lavrov, S. A., Zhimulev, I. F.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Chromatin
Chromatin - genetics
Chromatin - metabolism
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Drosophila melanogaster
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Gene expression
Gene Expression Regulation - physiology
Life Sciences
Metabolism
Molecular Biology
Polytene
Polytene Chromosomes - genetics
Polytene Chromosomes - metabolism
Proteins
Ribonucleic acid
RNA
RNA - biosynthesis
RNA - genetics
Transcription factors
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Summary:New data on the organization of genes entirely located in the open domains for chromatin transcription and occupying only one chromosome structure (interband) were obtained. The characteristic features of these genes are the small size (on average, 1–2 kb), depletion of the replicative complex proteins in the regulatory region, and the presence of specific motifs for binding transcription factors, as compared to the genes occupying two structures (interband and gray band). The biological function of these genes is associated primarily with the processes of gene expression and RNA metabolism.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672918060078