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Paraneoplastic neurological syndromes: a single institution 10-year case series
Background Given its rare incidence, there are few epidemiological case series on paraneoplastic neurologic syndromes (PNS). Methods We present a 10-year series compiled in the Section of Neuro-Oncology, Yale Cancer Center between 2002 and 2012. Results Twenty-five cases met the PNS Euro-network cri...
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Published in: | Journal of neuro-oncology 2019-01, Vol.141 (2), p.431-439 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Given its rare incidence, there are few epidemiological case series on paraneoplastic neurologic syndromes (PNS).
Methods
We present a 10-year series compiled in the Section of Neuro-Oncology, Yale Cancer Center between 2002 and 2012.
Results
Twenty-five cases met the PNS Euro-network criteria for definitive PNS. Most (64%; 16/25) had no known neoplasm. Cerebrospinal fluid pleocytosis declined logarithmically over time. Neuroimaging abnormalities were seen in 88% of cases (15/17), but with delayed onset. Therapeutic benefit correlated strongly to pre-treatment modified Rankin Scale (mRS) (p |
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ISSN: | 0167-594X 1573-7373 |
DOI: | 10.1007/s11060-018-03053-3 |