Loading…

Paraneoplastic neurological syndromes: a single institution 10-year case series

Background Given its rare incidence, there are few epidemiological case series on paraneoplastic neurologic syndromes (PNS). Methods We present a 10-year series compiled in the Section of Neuro-Oncology, Yale Cancer Center between 2002 and 2012. Results Twenty-five cases met the PNS Euro-network cri...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuro-oncology 2019-01, Vol.141 (2), p.431-439
Main Authors: Chan, Amy M., Baehring, Joachim M.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Given its rare incidence, there are few epidemiological case series on paraneoplastic neurologic syndromes (PNS). Methods We present a 10-year series compiled in the Section of Neuro-Oncology, Yale Cancer Center between 2002 and 2012. Results Twenty-five cases met the PNS Euro-network criteria for definitive PNS. Most (64%; 16/25) had no known neoplasm. Cerebrospinal fluid pleocytosis declined logarithmically over time. Neuroimaging abnormalities were seen in 88% of cases (15/17), but with delayed onset. Therapeutic benefit correlated strongly to pre-treatment modified Rankin Scale (mRS) (p 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-018-03053-3