Primary Urethral Melanoma: A Case Report and Literature Review

Patients with localized urethral melanoma have a high risk of recurrence and poor disease-specific survival. Multi-disciplinary approach including surgery, radiation therapy, and chemotherapy/immunotherapy is needed to maximize survival. Current research efforts include investigation of novel tyrosi...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2019-04, Vol.126, p.1-4
Main Authors: Davuluri, Meenakshi, Long, Bronwyn, Semple, Stacia, Villanueva-Siles, Esperanza, Aboumohamed, Ahmed
Format: Article
Language:English
Subjects:
Aged
Fatal Outcome
Female
Humans
Melanoma - diagnosis
Melanoma - therapy
Urethral Neoplasms - diagnosis
Urethral Neoplasms - therapy
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Summary:Patients with localized urethral melanoma have a high risk of recurrence and poor disease-specific survival. Multi-disciplinary approach including surgery, radiation therapy, and chemotherapy/immunotherapy is needed to maximize survival. Current research efforts include investigation of novel tyrosine kinases as well as the combination of targeted therapies with immunotherapies in this population. Combinations may provide a synergistic effect to overcome various obstacles to disease response.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2018.12.027