Mathematical Modeling of Open States in DNA Molecule Depending on the Deuterium Concentration in the Surrounding Liquid Media at Different Values of Hydrogen Bond Disruption Energy

The effect of the deuterium concentration in the surrounding liquid medium on the appearance of open states between the nitrogen bases of a double-stranded DNA molecule was investigated. It is shown that the nature of this effect depends on the magnitude of the energy of the hydrogen bond break.

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2018-11, Vol.483 (1), p.359-362
Main Authors: Dzhimak, S. S., Drobotenko, M. I., Basov, A. A., Svidlov, A. A., Fedulova, L. V., Lyasota, O. M., Baryshev, M. G.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Deoxyribonucleic acid
Deuterium
Deuterium - chemistry
DNA
DNA - chemistry
Hydrogen Bonding
Hydrogen bonds
Life Sciences
Mathematical models
Models, Molecular
Molecular Biology
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Description
Summary:The effect of the deuterium concentration in the surrounding liquid medium on the appearance of open states between the nitrogen bases of a double-stranded DNA molecule was investigated. It is shown that the nature of this effect depends on the magnitude of the energy of the hydrogen bond break.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672918060169