Comparison of quality of life measurements: EQ-5D-5L versus disease/treatment-specific measures in pulmonary embolism and deep vein thrombosis

Introduction There is a lack of performance comparisons of the generic quality of life tool EQ-5D-5L against disease- and treatment-specific measures in venous thromboembolism (VTE). The aim of this study was to compare EQ-5D-5L against the pulmonary embolism (PE)-specific PEmb-QoL and the deep vein...

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Published in:Quality of life research 2019-05, Vol.28 (5), p.1155-1177
Main Authors: Chuang, Ling-Hsiang, Cohen, Alexander T., Agnelli, Giancarlo, Gumbs, Pearl D., Bauersachs, Rupert, Kroep, Sonja, Gitt, Anselm K., Monreal, Manuel, Willich, Stefan N., van Hout, Ben
Format: Article
Language:English
Subjects:
Embolisms
Health risk assessment
Medicine
Medicine & Public Health
Public Health
Pulmonary embolisms
Quality of life
Quality of Life Research
Questionnaires
Sociology
Spanish language
Thromboembolism
Thrombosis
UTILITIES
Validity
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Summary:Introduction There is a lack of performance comparisons of the generic quality of life tool EQ-5D-5L against disease- and treatment-specific measures in venous thromboembolism (VTE). The aim of this study was to compare EQ-5D-5L against the pulmonary embolism (PE)-specific PEmb-QoL and the deep vein thrombosis (DVT)-specific VEINES-QOL/Sym, and PACT-Q2 (treatment-specific) questionnaires in five language settings. Methods PREFER in VTE was a non-interventional disease registry conducted between 2013 and 2014 in primary and secondary care across seven European countries with five languages, including English, French, German, Italian and Spanish. Consecutive patients with acute PE/DVT were enrolled and followed over 12 months. Only patients who completed all three questionnaires at baseline were included in the study sample. The psychometric properties examined included acceptability (missing, ceiling and floor effects), validity (convergent and known-groups validity), and responsiveness. Known groups validity and responsiveness were assessed using both effect size (Cohen’s d ) and relative efficiency ( F -statistic). All analyses were conducted in each language version and the total sample across all languages. Results A total of 1054 PE and 1537 DVT patients were included. 14% of PE and 10% of DVT patients had the maximum EQ-5D-5L index score. EQ-5D-5L was low to moderately correlated with other measures ( r  
ISSN:0962-9343
1573-2649
DOI:10.1007/s11136-018-2081-3