Multifunctionalization of Unactivated Cyclic Ketones via an Electrochemical Process: Access to Cyclic α‑Enaminones

The multifunctionalization of unactivated cyclic ketones was developed via an electrochemically intermolecular α-amination under metal-free conditions. The reaction can be carried out smoothly with a broad scope of the aromatic amines substrates under mild conditions, affording a variety of α-enamin...

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Bibliographic Details
Published in:Journal of organic chemistry 2019-02, Vol.84 (3), p.1647-1653
Main Authors: Hu, Kangfei, Qian, Peng, Su, Ji-Hu, Li, Zhibin, Wang, Jiawei, Zha, Zhenggen, Wang, Zhiyong
Format: Article
Language:English
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Summary:The multifunctionalization of unactivated cyclic ketones was developed via an electrochemically intermolecular α-amination under metal-free conditions. The reaction can be carried out smoothly with a broad scope of the aromatic amines substrates under mild conditions, affording a variety of α-enaminones with good to excellent yields in one step.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b02930