Long noncoding RNA MNX1‐AS1 contributes to lung cancer progression through the miR‐527/BRF2 pathway

Lung cancer belongs to a leading popular and malignant cancer around the world. However, the root mechanism underlying lung cancer progression remains unclear. Recently, long noncoding RNA (lncRNA) has been identified as important for tumorigenesis. LncRNA MNX1‐AS1 is proven to regulate colon adenoc...

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Bibliographic Details
Published in:Journal of cellular physiology 2019-08, Vol.234 (8), p.13843-13850
Main Authors: Liu, Haibo, Han, Leng, Liu, Zhengjia, Gao, Nan
Format: Article
Language:English
Subjects:
Adenocarcinoma
Animals
Base Sequence
BRF2
Cancer
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
Cervical cancer
Cervix
Colon
Colon cancer
Cytoplasm
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Gene Silencing
Glioblastoma
Human papillomavirus
Humans
long noncoding RNA
Lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Mice, Inbred BALB C
Mice, Nude
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
Migration
miR‐527
MNX1‐AS1
Neoplasm Invasiveness
Ovarian cancer
Restoration
Ribonucleic acid
RNA
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Signal Transduction
Transcription Factor TFIIIB - metabolism
Tumorigenesis
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Summary:Lung cancer belongs to a leading popular and malignant cancer around the world. However, the root mechanism underlying lung cancer progression remains unclear. Recently, long noncoding RNA (lncRNA) has been identified as important for tumorigenesis. LncRNA MNX1‐AS1 is proven to regulate colon adenocarcinoma, cervical cancer, glioblastoma, and ovarian cancer. Whether MNX1‐AS1 participates in lung cancer needs investigation. In our research, we found that MNX1‐AS1 was dramatically upregulated in lung cancer. MNX1‐AS1 upregulation indicated poor prognosis in lung cancer patients. Functionally, MNX1‐AS1 promoted lung cancer progression through regulating proliferation, migration, and invasion. Mechanistically, MNX1‐AS1 was found to locate in the cytoplasm and interact with miR‐527. Through inhibiting miR‐527 availability, MNX1‐AS1 facilitated BRF2 expression. Restoration of BRF2 rescued defects of proliferation, migration, and invasion caused by MNX1‐AS1 knockdown. Taken together, our study found a novel signaling pathway, namely MNX1‐AS1/miR‐527/BRF2 axis, involved in lung cancer progression. Long noncoding RNA MNX1‐AS1 contributes to lung cancer progression through miR‐527/BRF2 pathway
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.28064