Pooling analysis reveals that galectin‐1 is a reliable prognostic biomarker in various cancers

Galectin‐1 is reported to be upregulated in various human cancers. However, the relationship between galectin‐1 expression and cancer prognosis has not been systematically assessed. In this study, we searched PubMed, Web of Science, and Embase to collect all relevant studies and a meta‐analysis was...

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Bibliographic Details
Published in:Journal of cellular physiology 2019-08, Vol.234 (8), p.13788-13798
Main Authors: Huang, Ming‐Yu, He, Jia‐Peng, Zhang, Wen‐Qian, Liu, Ji‐Long
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor - analysis
Cancer
Confidence intervals
Galectin 1 - analysis
Galectin 1 - metabolism
galectin‐1
Gene expression
Genomes
Humans
Lymph nodes
Medical prognosis
Meta-analysis
Metastases
Neoplasms - metabolism
Neoplasms - mortality
overall survival
Prognosis
Survival
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Summary:Galectin‐1 is reported to be upregulated in various human cancers. However, the relationship between galectin‐1 expression and cancer prognosis has not been systematically assessed. In this study, we searched PubMed, Web of Science, and Embase to collect all relevant studies and a meta‐analysis was performed. We found that increased galectin‐1 expression was associated with tumor size (odds ratio [OR] = 1.75; 95% confidence interval [CI]: 1.06–2.89; p = 0.029), clinical stage (OR = 3.89; 95% CI: 2.40–6.31; p 
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.28059