Atypical Presentation of T-Cell Large Granular Lymphocytic Leukemia Mimicking Pleural Malignancy on 18F-FDG PET/CT

ABSTRACTT-cell large granular lymphocytic leukemia is a rare form of leukemia, caused by clonal proliferation of cytotoxic T-cells, characterized by modest lymphocytosis and cytopenias of other lineage with hepatosplenomegaly and relatively rare lymph nodal involvement. Involvement of other organs i...

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Bibliographic Details
Published in:Clinical nuclear medicine 2019-04, Vol.44 (4), p.e296-e297
Main Authors: Senthil, Raja, Visakh R, Arun, Pratap, Thara, Mahadevan, Pushpa, Gangadharan, V P
Format: Article
Language:English
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Summary:ABSTRACTT-cell large granular lymphocytic leukemia is a rare form of leukemia, caused by clonal proliferation of cytotoxic T-cells, characterized by modest lymphocytosis and cytopenias of other lineage with hepatosplenomegaly and relatively rare lymph nodal involvement. Involvement of other organs is extremely rare. It is predominantly an indolent disease and most of patients remain asymptomatic for a long period. We present a rare case of aggressive form (CD56 positive) of large granular lymphocytic leukemia with atypical presentations mimicking pleural malignancy on F-FDG PET/CT.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000002425