Parental IBD and Long-term Health Outcomes in the Offspring

For decades, the research on reproductive consequences in women with inflammatory bowel disease (IBD) has focused on short-term outcomes, including adverse pregnancy outcomes (eg, abruptio placenta, placenta previa, preeclampsia/eclampsia) and adverse birth outcomes (eg, small for gestational age, p...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2019-07, Vol.25 (8), p.1339-1348
Main Authors: Nørgård, Bente Mertz, Jølving, Line Riis, Larsen, Michael Due, Friedman, Sonia
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child Development
Child, Preschool
Female
Humans
Infant
Inflammatory Bowel Diseases - complications
Parents
Pregnancy
Pregnancy Complications - etiology
Pregnancy Outcome - epidemiology
Quality of Life
Time Factors
Young Adult
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Summary:For decades, the research on reproductive consequences in women with inflammatory bowel disease (IBD) has focused on short-term outcomes, including adverse pregnancy outcomes (eg, abruptio placenta, placenta previa, preeclampsia/eclampsia) and adverse birth outcomes (eg, small for gestational age, preterm birth, and congenital malformations). The long-term health outcomes of the children of parents with IBD have been studied to a much lesser extent, and there is a critical research gap in understanding the influence of parental IBD on long-term outcomes. In this review, we propose the reasons for this lack of evidence and highlight the weakest areas of the research on the impact of parental IBD on offspring health. We will focus on health outcomes in children of parents with IBD from an age of 1 year through childhood, adolescence, and adulthood.
ISSN:1078-0998
1536-4844
DOI:10.1093/ibd/izy396