Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens. HMOs prevent infection by serving as decoy receptors that competitively bind pathogens thus preventing pathogen attachment to host epithelial cell receptors. In a second mechanistic pathway, we...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2019-02, Vol.17 (7), p.1893-1900
Main Authors: Craft, Kelly M, Thomas, Harrison C, Townsend, Steven D
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Biofilms - drug effects
Breast milk
Carbohydrate Conformation
Epithelial cells
Humans
Microbial Sensitivity Tests
Milk, Human - chemistry
Oligosaccharides
Oligosaccharides - chemistry
Oligosaccharides - pharmacology
Pathogens
Permeability
Pharmacology
Pharmacophores
Polysaccharides
Receptors
Sialic Acids - chemistry
Sialic Acids - pharmacology
Streptococcus
Streptococcus - drug effects
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Summary:Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens. HMOs prevent infection by serving as decoy receptors that competitively bind pathogens thus preventing pathogen attachment to host epithelial cell receptors. In a second mechanistic pathway, we recently demonstrated that heterogenous HMO extracts exert antimicrobial action against Group B Streptococcus by increasing cellular permeability. As human milk contains ca. 200 unique glycans however, our understanding of which pharmacophores are most important to HMO antimicrobial activity remains immature. In the present study, we describe the first evaluation of the antimicrobial and antibiofilm activities of five structurally defined, ubiquitous sialylated HMOs against Group B Streptococcus.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02080a