Cockayne syndrome in siblings

[10] CS should be suspected in any child with microcephaly and postnatal growth failure, and any two of the following features: cold hands and feet, bilateral hearing loss, photosensitivity, joint contractures, intention tremor, typical facial features, loss of body fat, and cataract. Calcium channe...

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Bibliographic Details
Published in:Neurology India 2018-09, Vol.66 (5), p.1488-1490
Main Authors: Sowmini, P, Kumar, M, Velayutham, S, Revathy, G, Arunan, S
Format: Article
Language:English
Subjects:
Age
Aging
Ataxia
Atherosclerosis
Atrophy
Calcification
Cataracts
Consent
Cornea
Coronary vessels
Dwarfism
Electroencephalography
Hearing loss
Hypertension
Microcephaly
NMR
Nuclear magnetic resonance
Patients
Peripheral neuropathy
Siblings
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Summary:[10] CS should be suspected in any child with microcephaly and postnatal growth failure, and any two of the following features: cold hands and feet, bilateral hearing loss, photosensitivity, joint contractures, intention tremor, typical facial features, loss of body fat, and cataract. Calcium channel blockers and angiotensin converting enzyme inhibitors are the first-line drugs given for treating hypertension. The principal clinical implication of identification of this syndrome is to watch out for early atherosclerosis and its complications (stroke, myocardial infarction, accelerated hypertension, and renal failure), which can facilitate appropriate and timely treatment.
ISSN:0028-3886
1998-4022
DOI:10.4103/0028-3886.241349