Generalised arterial calcification in normoalbuminuric patients with type 1 diabetes with and without cardiovascular autonomic neuropathy

Background: Type 1 diabetes is associated with increased risk of cardiovascular disease and the diabetic complication cardiovascular autonomic neuropathy in itself entails increased cardiovascular risk by mechanisms not yet fully understood. Arterial calcification is an important predictor of cardio...

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Bibliographic Details
Published in:Diabetes & vascular disease research 2019-01, Vol.16 (1), p.98-102
Main Authors: Hjortkjær, Henrik Øder, Jensen, Tonny, Hilsted, Jannik, Mogensen, Ulrik Madvig, Rossing, Peter, Køber, Lars, Kofoed, Klaus Fuglsang
Format: Article
Language:English
Subjects:
Aged
Autonomic Nervous System - physiopathology
Cardiovascular System - innervation
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - etiology
Computed Tomography Angiography
Coronary Angiography - methods
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - etiology
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - diagnosis
Diabetic Angiopathies - diagnostic imaging
Diabetic Angiopathies - etiology
Diabetic Neuropathies - diagnosis
Diabetic Neuropathies - etiology
Diabetic Neuropathies - physiopathology
Female
Humans
Male
Middle Aged
Multidetector Computed Tomography
Prognosis
Risk Factors
Time Factors
Vascular Calcification - diagnostic imaging
Vascular Calcification - etiology
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Summary:Background: Type 1 diabetes is associated with increased risk of cardiovascular disease and the diabetic complication cardiovascular autonomic neuropathy in itself entails increased cardiovascular risk by mechanisms not yet fully understood. Arterial calcification is an important predictor of cardiovascular events; the aim of this study was to investigate the level of generalised arterial calcification in patients with long-term, normoalbuminuric type 1 diabetes and the association with cardiovascular autonomic neuropathy, as these factors have not been investigated in type 1 diabetes. Methods: Participants were examined for calcification of coronary and carotid arteries through non-contrast multi-detector computed tomography scans. Generalised arterial calcification was defined as the presence of calcium in both the coronary and carotid arteries. Results: A total of 53 patients with type 1 diabetes were included. Coronary and carotid artery calcium scores were correlated (r = 0.720, p 
ISSN:1479-1641
1752-8984
DOI:10.1177/1479164118805904