Proliferation arrest, selectivity, and chemosensitivity enhancement of cancer cells treated by a low-intensity alternating electric field

Elimination of serious side effects is a desired feature of cancer therapy. Alternating electric field treatment is one approach to the non-invasive treatment of cancer. The efficacy and safety of this novel therapy are confirmed for the treatment of glioblastoma multiforme. In the current study, we...

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Bibliographic Details
Published in:Biomedical microdevices 2018-10, Vol.20 (4), p.90-90, Article 90
Main Authors: Lei, Kin Fong, Hsieh, Shao-Chieh, Goh, Andrew, Kuo, Rei-Lin, Tsang, Ngan-Ming
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biomedical Engineering and Bioengineering
Biophysics
Cancer
Cancer therapies
Cell culture
Cell proliferation
Chemotherapy
Electric fields
Engineering
Engineering Fluid Dynamics
Fibroblasts
Glioblastoma
Glioblastoma multiforme
Nanotechnology
Regional development
Selectivity
Side effects
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Summary:Elimination of serious side effects is a desired feature of cancer therapy. Alternating electric field treatment is one approach to the non-invasive treatment of cancer. The efficacy and safety of this novel therapy are confirmed for the treatment of glioblastoma multiforme. In the current study, we co-cultured cancer cells and normal cells to investigate the selectivity and chemosensitivity enhancement of an electric field treatment. Cancer cells (cell line: HeLa and Huh7) and fibroblasts (cell line: HEL299) were cultured in an in-house–developed cell culture device embedded with stimulating electrodes. A low-intensity alternating electric field was applied to the culture. The field significantly induced proliferation arrest of the cancer cells, while had limited influence on the fibroblasts. Moreover, in combination with the anti-cancer drug, damage to the cancer cells was enhanced by the electric field. Thus, a lower dosage of the drug could be applied to achieve the same treatment effectiveness. This study provides evidence that low-intensity electric field treatment selectively induced proliferation arrest and enhanced the chemosensitivity of the cancer cells. This electro-chemotherapy could be developed and applied as a regional cancer therapy with minimal side effects.
ISSN:1387-2176
1572-8781
DOI:10.1007/s10544-018-0339-8