Effects of neutrophil–lymphocyte ratio on renal function and histologic lesions in patients with diabetic nephropathy

ABSTRACT Aim Chronic low‐grade inflammation related to diabetic nephropathy (DN) may affect the serum neutrophil–lymphocyte ratio (NLR). We aimed to examine the cross‐sectional relationships of NLR with renal function and structural lesions of DN in patients with type 2 diabetes mellitus (T2DM). Met...

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Published in:Nephrology (Carlton, Vic.) Vic.), 2019-11, Vol.24 (11), p.1115-1121
Main Authors: Zhang, Junlin, Zhang, Rui, Wang, Yiting, Wu, Yucheng, Li, Hanyu, Han, Qianqian, Guo, Ruikun, Wang, Tingli, Wang, Jiali, Grung, Pramesh, Liu, Fang
Format: Article
Language:English
Subjects:
Atrophy
Biopsy
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetic Nephropathies - blood
Diabetic Nephropathies - pathology
Diabetic Nephropathies - physiopathology
diabetic nephropathy
Female
Fibrinogen
Fibrosis
Glomerular Filtration Rate
histologic lesion
Humans
Kidney - pathology
Kidney - physiopathology
Lesions
Logistic Models
Lymphocytes
Male
Middle Aged
Nephropathy
Neutrophils
neutrophil–lymphocyte ratio
Regression analysis
Renal function
Retrospective Studies
type 2 diabetes mellitus
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Summary:ABSTRACT Aim Chronic low‐grade inflammation related to diabetic nephropathy (DN) may affect the serum neutrophil–lymphocyte ratio (NLR). We aimed to examine the cross‐sectional relationships of NLR with renal function and structural lesions of DN in patients with type 2 diabetes mellitus (T2DM). Methods The study retrospectively included 247 patients with T2DM and biopsy‐proven DN. The severity of different pathological lesions was evaluated based on the criteria of Renal Pathology Society. The patients were divided into two groups based on the median (2.42) of NLR level, group 1: NLR 
ISSN:1320-5358
1440-1797
DOI:10.1111/nep.13517