Assembly of a miRNA‐modified QCM sensor for miRNA recognition through response patterns

In this paper, a miRNA‐based quartz crystal microbalance (QCM) biosensor was fabricated and used to the rapid and effective sensing of miRNA. The specific hybridization between probe miRNA and different selected miRNAs (miR‐27a, miR‐27b, and Let‐7a) cause a different interaction mode, thus display d...

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Bibliographic Details
Published in:Journal of molecular recognition 2019-05, Vol.32 (5), p.e2772-n/a
Main Authors: Li, Xue, Ma, Ding, Zheng, Sheng‐Run, Fan, Jun, Wang, Tai, Dai, Zong, Zou, Xiao‐Yong, Teng, Shao‐Hua, Zhang, Wei‐Guang
Format: Article
Language:English
Subjects:
Biosensors
Hybridization
Microbalances
miRNA
miR‐27a
miR‐27b
QCM sensor
Quartz crystal microbalance
Quartz crystals
response pattern
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Summary:In this paper, a miRNA‐based quartz crystal microbalance (QCM) biosensor was fabricated and used to the rapid and effective sensing of miRNA. The specific hybridization between probe miRNA and different selected miRNAs (miR‐27a, miR‐27b, and Let‐7a) cause a different interaction mode, thus display different frequency change and response patterns in the QCM sensor, which were used to detect miR‐27a and miR‐27b. The selective sensing of miR‐27a in mixed miRNA solution was also achieved. This miRNA‐based QCM biosensor has the advantages of real‐time, label‐free, and short cycle detection. A miRNA‐based quartz crystal microbalance (QCM) biosensor was fabricated and used to the rapid and effective sensing of miRNA .
ISSN:0952-3499
1099-1352
DOI:10.1002/jmr.2772