Prognostic value of unifocal and multifocal positive surgical margins in a large series of robot-assisted radical prostatectomy for prostate cancer

Purpose To evaluate the prognostic value of positive surgical margins (PSM) focality for the prediction of biochemical recurrence (BCR) in patients undergoing robotic-assisted radical prostatectomy (RARP) for prostate cancer. Methods All men with clinically localized prostate cancer undergoing RARP...

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Bibliographic Details
Published in:World journal of urology 2019-09, Vol.37 (9), p.1837-1844
Main Authors: Keller, Etienne Xavier, Bachofner, Jacqueline, Britschgi, Anna Jelena, Saba, Karim, Mortezavi, Ashkan, Kaufmann, Basil, Fankhauser, Christian D., Wild, Peter, Sulser, Tullio, Hermanns, Thomas, Eberli, Daniel, Poyet, Cédric
Format: Article
Language:English
Subjects:
Aged
Cancer surgery
Humans
Male
Margins of Excision
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Oncology
Original Article
Prognosis
Prostate cancer
Prostatectomy
Prostatectomy - methods
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Retrospective Studies
Robotic surgery
Robotic Surgical Procedures
Tumors
Urological surgery
Urology
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Summary:Purpose To evaluate the prognostic value of positive surgical margins (PSM) focality for the prediction of biochemical recurrence (BCR) in patients undergoing robotic-assisted radical prostatectomy (RARP) for prostate cancer. Methods All men with clinically localized prostate cancer undergoing RARP in our tertiary referral centre between May 2005 and August 2016 were retrospectively identified. Patients with neoadjuvant therapy were excluded. Comparisons were made between cases with negative surgical margins (NSM), unifocal PSM (uPSM), and multifocal PSM (mPSM). Results From a total of 973 patients available for analysis, 315 (32%) had a PSM. In these patients, 190 had uPSM and 125 had mPSM. Focality of PSM was significantly associated with tumour stage and grade, preoperative PSA, and postoperative PSA persistence (all p  
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-018-2578-y