GAD1 gene polymorphisms are associated with bipolar I disorder and with blood homovanillic acid levels but not with plasma GABA levels

•G rs3749034, GG rs1978340-rs3749034 and GGT rs1978340-rs3749034-rs769404 are associated with BDI.•rs3749034 haplotypes containing the A allele protect against BDI and SZ.•GAD1 and COMT gene polymorphisms do not affect plasma GABA levels.•SNPs associated with higher GAD1 mRNA levels are related to l...

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Bibliographic Details
Published in:Neurochemistry international 2019-03, Vol.124, p.152-161
Main Authors: Arrúe, Aurora, González-Torres, Miguel Angel, Basterreche, Nieves, Arnaiz, Ainara, Olivas, Olga, Zamalloa, M. Isabel, Erkoreka, Leire, Catalán, Ana, Zumárraga, Mercedes
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - genetics
Catechol-O-Methyltransferase (COMT)
Female
gamma-Aminobutyric Acid - blood
Glutamate Decarboxylase - genetics
Glutamate decarboxylase 1 (GAD1)
Haplotypes - genetics
Homovanillic Acid - blood
Humans
Male
Middle Aged
Plasma gamma-aminobutyric acid
Plasma homovanillic acid
Polymorphism, Single Nucleotide - genetics
Schizophrenia
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Summary:•G rs3749034, GG rs1978340-rs3749034 and GGT rs1978340-rs3749034-rs769404 are associated with BDI.•rs3749034 haplotypes containing the A allele protect against BDI and SZ.•GAD1 and COMT gene polymorphisms do not affect plasma GABA levels.•SNPs associated with higher GAD1 mRNA levels are related to low plasma HVA levels.•Associations of pHVA levels with SNPs did not differ between patients and controls.
ISSN:0197-0186
1872-9754
DOI:10.1016/j.neuint.2019.01.004