Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice

Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of do...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-01, Vol.166 (3), p.326-329
Main Authors: Davydova, T. V., Gruden, M. A., Kudrin, V. S., Narkevich, V. B., Vetrile, L. A., Zakharova, I. A., Sewell, R. D. E.
Format: Article
Language:English
Subjects:
Aging
Amino acids
Antibodies
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cortex (frontal)
Dopamine
Immunoglobulins
Internal Medicine
Intranasal administration
Laboratory Medicine
Locomotion
Locomotor activity
Metabolism
Metabolites
Open-field behavior
Pathology
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Summary:Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04343-0