An optimal strategy for prediction of sudden cardiac death through a pioneering feature-selection approach from HRV signal

• Published in: Computer methods and programs in biomedicine 2019-02, Vol.169, p.19-36
• Main Authors: Ebrahimzadeh, Elias, Foroutan, Alireza, Shams, Mohammad, Baradaran, Raheleh, Rajabion, Lila, Joulani, Mohammadamin, Fayaz, Farahnaz
• Format: Article
• Language: English
• Subjects: Algorithms; Death, Sudden, Cardiac; Feature reduction; Forecasting; Heart Rate - physiology; Heart rate variability; Humans; Signal Processing, Computer-Assisted; Sudden cardiac death; Time Local Subset Feature Selection
• ISSN: 0169-2607; 1872-7565
• DOI: 10.1016/j.cmpb.2018.12.001

•The proposed method has increased the SCD prediction time with a high accuracy.•Through defining a Utility Function and employing statistical analysis, the alarm threshold has been effectively determined as 84%.•The most informative features are presented according to the number of times they have been chosen in the rank-based selection.•The principal features in each time interval are discussed and the importance of each type of processing methods at different times before the onset was drawn into focus.•This approach allows for the interpretation of clinical signs, considering the plurality of features in each minute. Taking into consideration the critical importance of Sudden cardiac death (SCD), as it could be the first and the last heart condition to be diagnosed in a person while continuing to claim millions of lives around the world, prediction of sudden cardiac death has increasingly been regarded as a matter of substantive significance. This study does not seek to once again define features to predict and detect SCD, as there already has been adequate discussion addressing feature extraction in our previous works and other recent studies. What seems to be lacking attention is the need for an appropriate strategy to manage the extracted features to such an extent that the best classification is presented. To this end, deploying a suitable tactic to select extracted features could bring about outstanding results compared to other works in the literature. This research has accordingly applied a novel and automated approach to Local Feature Subset Selection through the most rigorous methodologies, which have formerly been developed in previous works of this team, for extracting features from nonlinear, time-frequency and classical processes. We are therefore enabled to select features that differ from one another in each minute before the incident through the agency of optimal feature selection in each one-minute interval of the signal. Using the proposed algorithm, SCD can be predicted 13 min before the onset, thus, better results are achieved compared to other techniques proposed in this field. Additionally, through defining a Utility Function and employing statistical analysis the alarm threshold has been effectively determined as 84% for the prediction accuracy. Having selected the best combination of features, based on their ability to generate the highest classification accuracy, the two classes are classified by means of the Multilayer Percept