Prominence of nestin-expressing Schwann cells in bone marrow of patients with myelodysplastic syndromes with severe fibrosis

Nestin-expressing stromal cells (NESCs) and Schwann cells in the bone marrow (BM) play crucial roles as a niche for normal hematopoietic stem cells in mice. It has been reported that both types of cells are decreased in myeloproliferative neoplasms in patients and also in a mouse model, whereas an i...

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Bibliographic Details
Published in:International journal of hematology 2019-03, Vol.109 (3), p.309-318
Main Authors: Cao-Sy, Luan, Obara, Naoshi, Sakamoto, Tatsuhiro, Kato, Takayasu, Hattori, Keiichiro, Sakashita, Shingo, Nannya, Yasuhito, Ogawa, Seishi, Harada, Hironori, Sakata-Yanagimoto, Mamiko, Nishikii, Hidekazu, Chiba, Shigeru
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Axons
Bone marrow
Disorders
Erythrocytes
Fibrosis
Glial fibrillary acidic protein
Hematology
Hematopoietic stem cells
Leukemia
Medicine
Medicine & Public Health
Myelodysplastic syndrome
Myelodysplastic syndromes
Myeloid leukemia
Neoplasms
Nestin
Oncology
Original Article
Patients
Proteins
Schwann cells
Stem cell transplantation
Stem cells
Stromal cells
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Summary:Nestin-expressing stromal cells (NESCs) and Schwann cells in the bone marrow (BM) play crucial roles as a niche for normal hematopoietic stem cells in mice. It has been reported that both types of cells are decreased in myeloproliferative neoplasms in patients and also in a mouse model, whereas an increase in NESCs was reported in acute myeloid leukemia. It is thus of interest whether and how these BM stromal cells are structured in myelodysplastic syndromes (MDS). Here, we focused on NESCs and glial fibrillary acidic protein (GFAP)-expressing cells in the BM of MDS patients. We found a marked increase of NESCs in MDS with fibrosis (MDS-F) at a high frequency (9/19; 47.4%), but not in MDS without fibrosis (0/26; 0%). Intriguingly, in eight of the nine (88.9%) MDS-F cases with elevated NESCs, a majority of NESCs also expressed GFAP, with an additional increase in GFAP single-positive cells. Furthermore, in seven of them, we found a prominent structure characterized by neurofilament heavy chain staining surrounded by NESCs with GFAP expression. This structure may represent peripheral nerve axons surrounded by Schwann cells, and could be relevant to the pathophysiology of MDS-F.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-018-02576-9