Atrophy of the ipsilateral mammillary body in unilateral hippocampal sclerosis shown by thin-slice-reconstructed volumetric analysis

Purpose Conventional volumetric analysis could not detect ipsilateral atrophy of the mammillary body in patients with unilateral hippocampal sclerosis. By using thin-slice-reconstructed volumetric analysis, we investigated whether the mammillary body volume is smaller on the hippocampal sclerosis si...

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Bibliographic Details
Published in:Neuroradiology 2019-05, Vol.61 (5), p.515-523
Main Authors: Morishita, Yohei, Mugikura, Shunji, Mori, Naoko, Tamura, Hajime, Sato, Shiho, Akashi, Toshiaki, Jin, Kazutaka, Nakasato, Nobukazu, Takase, Kei
Format: Article
Language:English
Subjects:
Atrophy
Body volume (biology)
Diagnostic Neuroradiology
Dinosaurs
Hippocampus
Image reconstruction
Imaging
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Patients
Radiology
Sclerosis
Thickness
Veterinarians
Volumetric analysis
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Summary:Purpose Conventional volumetric analysis could not detect ipsilateral atrophy of the mammillary body in patients with unilateral hippocampal sclerosis. By using thin-slice-reconstructed volumetric analysis, we investigated whether the mammillary body volume is smaller on the hippocampal sclerosis side than in healthy subjects or the non-hippocampal sclerosis side. Methods This retrospective study included 45 patients with unilateral hippocampal sclerosis and 30 healthy subjects. Three-dimensional T1WI of 1 mm thicknesses were oversampled to a thickness of 0.2 mm (thin-slice-reconstructed images), and the mammillary bodies were segmented manually to determine mammillary body volume on each side. Mammillary body volumes on the hippocampal sclerosis side were compared with those in healthy subjects or the non-hippocampal sclerosis side. Results In patients with right hippocampal sclerosis, right mammillary body volume was both significantly smaller than that in healthy subjects (30.3 ± 10.3 vs. 43.3 ± 8.07 mm 3 , P  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-019-02158-4