ZWINT is the next potential target for lung cancer therapy

Purpose We aimed to analyze the expression of ZWINT, NUSAP1, DLGAP5, and PRC1 in tumor tissues and adjacent tissues with public data. Methods The expression patterns of four genes were detected in cancer tissues and adjacent tissues by qRT-PCR. The overall survival analysis was used to explore these...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2019-03, Vol.145 (3), p.661-673
Main Authors: Peng, Fang, Li, Qiang, Niu, Shao-Qing, Shen, Guo-Ping, Luo, Ying, Chen, Ming, Bao, Yong
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Adenocarcinoma
Animals
Apoptosis
Apoptosis - genetics
Biomarkers, Tumor - analysis
Cancer Research
Cancer therapies
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Cell adhesion & migration
Cell Cycle Proteins - analysis
Cell Cycle Proteins - biosynthesis
Cell Line, Tumor
Cell migration
Cell Movement - genetics
Cell proliferation
Cell Proliferation - genetics
Gene expression
Gene Knockdown Techniques
Genes
Hematology
Heterografts
Humans
Internal Medicine
Intracellular Signaling Peptides and Proteins - analysis
Intracellular Signaling Peptides and Proteins - biosynthesis
Kaplan-Meier Estimate
Lung cancer
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Medical prognosis
Medicine
Medicine & Public Health
Mice
Mice, Nude
Microtubule-Associated Proteins - analysis
Microtubule-Associated Proteins - biosynthesis
Neoplasm Proteins - analysis
Neoplasm Proteins - biosynthesis
Nuclear Proteins - analysis
Nuclear Proteins - biosynthesis
Oncology
Original Article – Cancer Research
p53 Protein
Squamous cell carcinoma
Survival analysis
Tumor necrosis factor
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Summary:Purpose We aimed to analyze the expression of ZWINT, NUSAP1, DLGAP5, and PRC1 in tumor tissues and adjacent tissues with public data. Methods The expression patterns of four genes were detected in cancer tissues and adjacent tissues by qRT-PCR. The overall survival analysis was used to explore these genes in lung adenocarcinoma and squamous cell carcinoma patients. Knockdown assays were used to select the most suitable gene among these four genes. Cell function assays with the knockdown gene were conducted in A549 and NCL H226 cells. The role of the knockdown gene in lung cancer was dissected in a mice tumor model. Transcriptome sequencing analyses with the knockdown gene were analyzed. Results Overexpression of these genes was significantly detected in cancer tissues ( P  
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-018-2823-1