Inflammatory cytokines expression in Wilson’s disease

• Published in: Neurological sciences 2019-05, Vol.40 (5), p.1059-1066
• Main Authors: Wu, Peng, Dong, Jianjian, Cheng, Nan, Yang, Renmin, Han, Yongshen, Han, Yongzhu
• Format: Article
• Language: English
• Subjects: Antibody microarrays; Brief Communication; Chemokines; Copper; Cytokines; Helper cells; Hereditary diseases; Inflammation; Interleukin 10; Interleukin 13; Interleukin 2; Interleukin 23; Interleukin 5; Lymphocytes T; Medicine; Medicine & Public Health; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Plasma levels; Psychiatry; Transforming growth factor-b1; Tumor necrosis factor-α
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-018-3680-z

Background Wilson’s disease (WD) is an autosomal recessive inherited disorder of copper (Cu) metabolism. Inflammation is a self-defensive reaction aimed at eliminating or neutralizing injurious stimuli, and restoring tissue integrity. Copper deposition may lead to inflammation in the organs and tissues of WD patients. Objective The aim of this study was to compare the plasma levels of inflammatory cytokines in patients with WD and healthy group, and also to assess whether inflammatory cytokines affects the clinical manifestation of WD. Methods Ninety-nine patients with WD and 32 controls were recruited for this study. Ray Biotech antibody microarray was used to detect the levels of plasma inflammatory cytokines. Results and conclusion Our results showed significant increase in T helper (Th) 1 cells (IL-2, TNF-α, and TNF-β), Th2 cells (IL-5, IL-10, and IL-13), and Th17 (IL-23) ( p