Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729

Trichobamide A (1), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus Trichobotrys effuse 4729. Trichobamide A (1) showed significant inhibition of the proliferation of two glioma cell lines, U251 and SNB19....

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019, Vol.55 (10), p.1438-1441
Main Authors: Chen, Senhua, Shen, Hongjie, Zhang, Panpan, Cheng, Hongwei, Dai, Xingliang, Liu, Lan
Format: Article
Language:English
Subjects:
Crystallography
Fungi
Gene expression
NMR
Nuclear magnetic resonance
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Summary:Trichobamide A (1), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus Trichobotrys effuse 4729. Trichobamide A (1) showed significant inhibition of the proliferation of two glioma cell lines, U251 and SNB19. It induced the up-regulation of P53 expression, which in turn induces the up-regulation of downstream pro-apoptotic gene expression and the down-regulation of anti-apoptotic gene expression.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc08970a