Destabilization of DNA through interstrand crosslinking by UO22

UO22+ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π–π stacking between the two nucleobases in the vicinity of UO22+-bound phosphate. Thereby, the fra...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-01, Vol.55 (14), p.2015-2018
Main Authors: Rossberg, André, Abe, Takaya, Okuwaki, Koji, Barkleit, Astrid, Fukuzawa, Kaori, Nakano, Tatsuya, Mochizuki, Yuji, Tsushima, Satoru
Format: Article
Language:English
Subjects:
Crosslinking
Deoxyribonucleic acid
Destabilization
DNA
Factor analysis
Fragility
Hydrogen bonds
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Summary:UO22+ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π–π stacking between the two nucleobases in the vicinity of UO22+-bound phosphate. Thereby, the fragility of the DNA backbone increased upon UO22+ binding.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc09329f