Relation between plasma Apelin level and peripheral neuropathy in Type 2 diabetic patients

Peripheral neuropathy is one of the most common complications of both type 1 and type 2 diabetes, Long standing peripheral neuropathic pain associated with peripheral neuropathy occurs in one of six diabetic subjects, Apelin is a peptide secreted from adipocytes that seems to be beneficial in early...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2019-01, Vol.13 (1), p.626-629
Main Authors: Hosny, Salwa Seddik, Nasr, Merhan Samy, Ibrahim, Rana Hashem, YousryHelal, Zainb
Format: Article
Language:English
Subjects:
Adult
Apelin - blood
Blood Glucose
Case-Control Studies
diabetes duration
Diabetes Mellitus, Type 2 - complications
Diabetic Neuropathies - complications
Diabetic Neuropathies - diagnosis
Diabeticneuropathy
Humans
Insulin
Middle Aged
Multivariate Analysis
Regression Analysis
Serum Apelin
Type 2 diabetes
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Summary:Peripheral neuropathy is one of the most common complications of both type 1 and type 2 diabetes, Long standing peripheral neuropathic pain associated with peripheral neuropathy occurs in one of six diabetic subjects, Apelin is a peptide secreted from adipocytes that seems to be beneficial in early detection of diabetic neuropathy, Itisnotedthatitincreasesindiabeticpatients and more in those with neuropathy. We aimed to study the relation between plasma apelin levels and peripheral neuropathy in a sample of type 2 egyptian diabetic patients The current study included 60 subjects with type 2 diabetes divided into 30 with diabetic neuropathy (group I) and 30 without diabetic neuropathy (group II) and 20 healthy subjects as a control group (group III). Fasting plasma glucose, Fasting insulin, HOMA- IR, Hemoglobin A1c, Total cholesterol, Triglycerides, High density lipoproteins, Low density lipoprotiens and Apelin levels were assessed. Neurological evaluation in diabetic subjects wasdone by nerve conduction study and clinical examination by using microfilament and tunning fork. On comparing the three studied groups a statistical significant difference in plasma Apelin levels was found (p 
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2018.11.027