Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects

• Published in: International Journal of Obesity 2020-01, Vol.44 (1), p.159-166
• Main Authors: Sapunar, Jorge, Fonseca, Luis, Molina, Víctor, Ortiz, Eugenia, Barra, Maria Ines, Reimer, Camila, Charles, Maria, Schneider, Constance, Ortiz, Manuel, Brito, Roberto, Manríquez, Víctor, Pavez, Monica, Cerda, Alvaro
• Format: Article
• Language: English
• Subjects: 692/163/2743/393; 692/499; 82/1; 82/80; Adenoviridae - immunology; Adenoviridae Infections - complications; Adenoviridae Infections - epidemiology; Adenoviridae Infections - immunology; Adenovirus; Adenoviruses; Adiponectin; Adipose tissue; Adult; Advertising executives; Anthropometry; Antibodies, Viral - blood; Antidiabetics; Blood glucose; Blood Glucose - analysis; Case-Control Studies; Children; Chile; Cholesterol; Dextrose; Diabetes mellitus; Diabetes therapy; Enzyme-linked immunosorbent assay; Enzymes; Epidemiology; Female; Glucose; Health aspects; Health Promotion and Disease Prevention; Health risk assessment; Humans; Hypoglycemic agents; Insulin; Internal Medicine; Laboratory tests; Leptin; Leptin - blood; Lipids; Lipoproteins (very low density); Male; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Obesity; Obesity - complications; Obesity - epidemiology; Population; Population studies; Public Health; Risk factors; Risk management; Seroepidemiologic Studies; Serology; Triglycerides; Type 2 diabetes
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/s41366-019-0321-4

Background Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean population. Subjects and methods Clinical and anthropometric data were obtained and blood samples were drawn from 99 lean (BMI: 18.5–24.9 kg/m 2 ) and 151 obese (BMI > 30 kg/m 2 ) subjects. Laboratory tests included lipid profile as well as glucose, insulin, leptin, and adiponectin levels. Ad-36 seropositivity was evaluated in serum samples by enzyme-linked immunosorbent assay. Results Seroprevalence of Ad-36 was higher in the obese group (58%) than in lean controls (34%) demonstrating that individuals previously infected with Ad-36 have higher risk of obesity in the study population (OR: 2.67, 95%CI: 1.58–4.51, p