Serum levels of phthalates and bisphenol-A in patients with primary ovarian insufficiency

Objectives: Phthalates and bisphenol-A (BPA) may pose a risk for human reproduction. Adverse effects of endocrine disturbing chemicals on animal ovaries have been proposed previously. This study was designed to measure the concentrations of phthalate diesters or their metabolites in serum to evaluat...

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Bibliographic Details
Published in:Gynecological endocrinology 2019-04, Vol.35 (4), p.364-367
Main Authors: Özel, Şule, Tokmak, Aytekin, Aykut, Osman, Aktulay, Ayla, Hançerlioğulları, Necati, Engin Ustun, Yaprak
Format: Article
Language:English
Subjects:
female reproductive toxicology
ovarian toxicology
ovary
Phthalates
phthalic acid
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Summary:Objectives: Phthalates and bisphenol-A (BPA) may pose a risk for human reproduction. Adverse effects of endocrine disturbing chemicals on animal ovaries have been proposed previously. This study was designed to measure the concentrations of phthalate diesters or their metabolites in serum to evaluate their relevance with primary ovarian insufficiency (POI). Methods: This study was designed as a cross sectional and case-control study. The study group consisted of 30 women diagnosed with POI whereas 30 healthy fertile women without any systemic diseases were recruited as a control group. The two groups were matched with respect to age and body mass index and tobacco smoking. Serum phthalate diesters and BPA levels were measured in both groups. Results: The mean serum level of mono-buthyl phthalate (MBP) was statistically significantly higher in POI group than in control group (8.45 ± 4.2 vs. 5.0 ± 3.47 ng/mL, p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2018.1534951