Dose vitamin D supplementations improve peripheral diabetic neuropathy? A before-after clinical trial

Peripheral neuropathy is a common complication of diabetes mellitus. This study was set to assess the effect of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes (T2DM). This study was a quasi-experimental trial in Yazd diabetic research center. Sixty T2DM subjects...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2019-01, Vol.13 (1), p.890-893
Main Authors: Ghadiri-Anari, Akram, Mozafari, Zohre, Gholami, Somaye, Khodaei, Seyed-Ali, Aboutorabi-zarchi, Marzieh, Sepehri, Fariba, Nadjarzade, Azade, Rahmanian, Masoud, Namiranian, Nasim
Format: Article
Language:English
Subjects:
Adult
Aged
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
Diabetic Neuropathies - blood
Diabetic Neuropathies - drug therapy
Diabetic Neuropathies - epidemiology
Dietary Supplements
Female
Humans
Iran - epidemiology
Male
Middle Aged
Neuropathy
Vitamin D
Vitamin D - administration & dosage
Vitamin D - blood
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Summary:Peripheral neuropathy is a common complication of diabetes mellitus. This study was set to assess the effect of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes (T2DM). This study was a quasi-experimental trial in Yazd diabetic research center. Sixty T2DM subjects (30–65 years old) with painful diabetic neuropathy enrolled in this study from March 2017 till April 2018. Patients received weekly 50000 IU of vitamin D3 for 12 weeks orally. Evaluation of diabetic neuropathy was performed by using Michigan Neuropathy Screening Instrument (MNSI) before and after trial. Also fasting plasma glucose, HbA1c, calcium and vitamin D checked before and after the trial. SPSS version 20 software was used for statistical analysis. P ≤ 0.05 was considered to be statistically significant. Among 60 T2DM patients, 58 completed the study. Most of them (53.4%) were male. At the end of study, HbA1c, vitamin D, MNSI (both questionnaire and physical examination) improved that is statistically significant (p-value:
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2018.12.014