Nosocomial Mycobacterium tuberculosis transmission by brief casual contact identified using comparative genomics

This paper reports a case of nosocomial transmission of Mycobacterium tuberculosis by brief casual contact. Routine variable number tandem repeat typing in Yamagata Prefecture, Japan found that M. tuberculosis clinical isolates from two patients showed indistinguishable genotypes. The patients had a...

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Bibliographic Details
Published in:The Journal of hospital infection 2019-05, Vol.102 (1), p.116-119
Main Authors: Seto, J., Otani, Y., Wada, T., Suzuki, Y., Ikeda, T., Araki, K., Mizuta, K., Ahiko, T.
Format: Article
Language:English
Subjects:
Casual contact
Comparative genomics
Mycobacterium tuberculosis
Recent tuberculosis transmission
Variable number tandem repeat typing
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Summary:This paper reports a case of nosocomial transmission of Mycobacterium tuberculosis by brief casual contact. Routine variable number tandem repeat typing in Yamagata Prefecture, Japan found that M. tuberculosis clinical isolates from two patients showed indistinguishable genotypes. The patients had an epidemiological relationship of sharing a waiting room in a hospital on the same day. As comparative genomics detected only two single nucleotide variants between the isolates, it was concluded that recent tuberculosis transmission occurred in the waiting room. These results indicate that the physical separation of infectious tuberculosis patients is an essential control measure for preventing unpredictable nosocomial transmission by casual contact.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2019.01.002