Implications of dried blood spot testing for congenital CMV on management of children with hearing loss: A preliminary report

Non-genetic, congenital sensorineural hearing loss (cSNHL) is commonly caused by congenital CMV infection (cCMV). Hearing loss related to cCMV is variable in degree, often progressive, and can affect one or both ears. We sought to examine the outcomes of DBS testing in California, and the hearing ou...

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Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2019-04, Vol.119, p.10-14
Main Authors: Lee, Edward R., Chan, Dylan K.
Format: Article
Language:English
Subjects:
Congenital cytomegalovirus infection
Pediatric hearing loss
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Summary:Non-genetic, congenital sensorineural hearing loss (cSNHL) is commonly caused by congenital CMV infection (cCMV). Hearing loss related to cCMV is variable in degree, often progressive, and can affect one or both ears. We sought to examine the outcomes of DBS testing in California, and the hearing outcomes of cCMV-positive children. This is a retrospective study of patients with SNHL of unknown etiology aged 6 months to 17 years old presenting to a tertiary care pediatric center and evaluated for cCMV by DBS testing. 114 children (228 ears) with SNHL of unknown origin were included. 6/114 (5.3%) tested positive for cCMV versus 108/114 (94.7%), who tested negative. None of the cCMV-positive children had symmetric bilateral hearing loss, compared with 56.5% (61/108) of cCMV-negative children (p 
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2018.12.029