Anterior segment optical coherence tomography (AS‐OCT) as a new method of detecting copper deposits forming the Kayser–Fleischer ring in patients with Wilson disease

Purpose Kayser–Fleischer ring pathognomonic for Wilson disease (WD) is formed of corneal copper deposits present predominantly within the anterior chamber angle at the Schwalbe's line. The slit‐lamp assessment commonly used as a standard of care cannot detect them early enough, as the angle vie...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2019-08, Vol.97 (5), p.e757-e760
Main Authors: Broniek‐Kowalik, Karina, Dzieżyc, Karolina, Litwin, Tomasz, Członkowska, Anna, Szaflik, Jacek P.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anterior chamber
Anterior Eye Segment - diagnostic imaging
Anterior Eye Segment - metabolism
anterior segment optical coherence tomography
Copper
Copper - metabolism
copper deposit
Cornea
Corneal Diseases - diagnosis
Corneal Diseases - etiology
Corneal Diseases - metabolism
Deposits
Female
Follow-Up Studies
Hepatolenticular Degeneration - complications
Hepatolenticular Degeneration - diagnosis
Hepatolenticular Degeneration - metabolism
Humans
Kayser–Fleischer ring
Male
Middle Aged
Optical Coherence Tomography
Reproducibility of Results
Slit Lamp Microscopy
Time Factors
Tomography
Tomography, Optical Coherence - methods
Wilson disease
Wilson's disease
Young Adult
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Summary:Purpose Kayser–Fleischer ring pathognomonic for Wilson disease (WD) is formed of corneal copper deposits present predominantly within the anterior chamber angle at the Schwalbe's line. The slit‐lamp assessment commonly used as a standard of care cannot detect them early enough, as the angle view is obscured by the corneal limbus. The aim of the research was to evaluate the anterior segment optical coherence tomography (AS‐OCT), as objective diagnostic assessment of copper deposits forming KF ring in patients with WD. Methods Twenty‐nine subjects (17 women) and twenty‐nine controls (14 women) were enrolled and underwent slit lamp and AS‐OCT assessment. Results Kayser–Fleischer ring was not detected – either with a slit lamp or with AS‐OCT – in any of the controls. Fifteen subjects presenting without KF ring at a slit‐lamp examination were found to have a KF ring when examined with AS‐OCT (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.14009