Modification of chitosan and chitosan nanoparticle by long chain pyridinium compounds: Synthesis, characterization, antibacterial, and antioxidant activities

• Published in: Carbohydrate polymers 2019-03, Vol.208, p.477-485
• Main Authors: Omidi, Sakineh, Kakanejadifard, Ali
• Format: Article
• Language: English
• Subjects: Antibacterial activity; Antioxidant activity; Chitosan; Quaternary pyridinium compounds
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2018.12.097

[Display omitted] •The long chain pyridinium salts were grafted on the chitosan and chitosan nanoparticle.•The QAC-chitosan derivatives were evaluated for antibacterial and antioxidant activities.•They showed significant effect against Gram-positive bacteria and a mild activity against DPPH radicals. Chitosan is an antibacterial biopolymer and conjugation of it with other antimicrobial agents can be a valuable method to improve the potential application of the resultant materials in the various industries such as cosmetics, food and packaging materials. In this work, a series of quaternary pyridinium compounds were synthesized; then to achieve developed biological properties, they were attached to the chitosan and chitosan nanoparticles. The formation of chitosan derivatives was evinced by FT-IR, 1H and 13C NMR, UV–vis and EDX spectroscopy. The morphology of samples was detected by FE-SEM, TEM and AFM images. The QAC-chitosan hybrids were investigated for antibacterial activity against two Gram-positive and two Gram-negative bacteria, and they showed a significant effect on the Gram-positive bacteria. DPPH-radical scavenging assay shows mild improvement in antioxidant activity of new chitosan derivatives.