Atrial fibrosis in non–atrial fibrillation individuals and prediction of atrial fibrillation by use of late gadolinium enhancement magnetic resonance imaging

• Published in: Journal of cardiovascular electrophysiology 2019-04, Vol.30 (4), p.550-556
• Main Authors: Siebermair, Johannes, Suksaranjit, Promporn, McGann, Christopher J, Peterson, Kathryn A, Kheirkhahan, Mobin, Baher, Alex A, Damal, Kavitha, Wakili, Reza, Marrouche, Nassir F, Wilson, Brent D
• Format: Article
• Language: English
• Subjects: atrial fibrillation (AF); atrial fibrosis; Body mass; Body mass index; Cardiac arrhythmia; Cardiovascular disease; Cardiovascular diseases; cardiovascular imaging; Coronary artery disease; Fibrillation; Fibrosis; Gadolinium; Heart diseases; late gadolinium enhancement (LGE); Magnetic resonance imaging; magnetic resonance imaging (MRI); NMR; Nuclear magnetic resonance; Resonance; Risk factors; Ventricle; Weight reduction
• ISSN: 1045-3873; 1540-8167
• DOI: 10.1111/jce.13846

Introduction Besides the traditional concept of atrial fibrillation (AF) perpetuating atrial structural remodeling, there is increasing evidence that atrial fibrosis might precede AF, highlighting the need for better characterization of the fibrotic substrate. We aimed to assess atrial fibrosis by use of late gadolinium enhancement magnetic resonance imaging (LGE‐MRI) in non‐AF individuals and to identify predisposing risk factors. A second aim was to establish a risk score for the prevalence of AF using atrial fibrosis in addition to established clinical variables. Methods and Results Non‐AF individuals without structural heart disease (n = 91) and matched AF controls (n = 91) underwent MRI for assessment of LGE. According to the established UTAH classification, atrial LGE ≥20% was considered extensive. Mean left atrial (LA) fibrosis in non‐AF and AF individuals were 8.8 ± 6.5% and 12.5 ± 5.8%, respectively. Body mass index (BMI) >30 kg/m 2 and LA volume were predictors of atrial fibrosis. Diastolic function was not significantly different with respect to atrial fibrosis. A novel scoring system for the prevalence of AF (2 points for arterial hypertension and/or left ventricular ejection fraction 6%) was derived demonstrating that patients in the intermediate/high‐risk group had a significantly increased risk of AF. Conclusion This study reports unexpectedly high atrial fibrosis in non‐AF patients without apparent heart disease, highlighting the concept that structural fibrotic alterations may precede AF onset in a significant proportion of individuals. BMI as a predictor of atrial fibrosis suggests that lifestyle and drug intervention, that is, weight reduction, could positively influence fibrosis development. The derived risk score for AF prevalence provides the basis for prospective studies on AF incidence.