Silent synapse: A new player in visual cortex critical period plasticity

During critical period, the heightened plasticity in neocortex opens a time window when, with proper external environmental stimuli, experience dependent refinement processes help to optimize the function of neuronal networks. With the closure of critical periods, the gradually decreased plasticity...

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Bibliographic Details
Published in:Pharmacological research 2019-03, Vol.141, p.586-590
Main Author: Huang, Xiaojie
Format: Article
Language:English
Subjects:
Animals
Critical period
Hebbian plasticity
Humans
Inhibitory maturation
Nerve Net - physiology
Neuronal Plasticity
PSD-95
Receptors, AMPA - metabolism
Silent synapse
Synapses - physiology
Visual Cortex - physiology
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Summary:During critical period, the heightened plasticity in neocortex opens a time window when, with proper external environmental stimuli, experience dependent refinement processes help to optimize the function of neuronal networks. With the closure of critical periods, the gradually decreased plasticity leaves a mature system which is stable to perform its function but with limited plasticity for changes in the adult. In order to gain more detailed knowledge about critical period plasticity, ocular dominance plasticity in primary visual cortex has been used as a study model to test plasticity levels in neural circuits. Since then, multiple cellular and molecular mechanisms have been proposed. Among them, the abundance of AMPA receptor silent synapses, as substrates for Hebbian plasticity, is shown to be closely related to not only critical period plasticity, but also the network refinement at glutamatergic synapses of principal neurons. Here, I discuss the role of silent synapses and how they interact with other known mechanisms involved in critical period plasticity.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2019.01.031