Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach

Purpose A structural equation model (SEM) was used to test multiple and simultaneous relationships between socio-demographic factors, dietary patterns, biochemical levels of folate, vitamin B12, docosahexaenoic acid (DHA), and its effects on homocysteine (Hcy) level. Methods Socio-demographic and li...

Full description

Saved in:
Bibliographic Details
Published in:European journal of nutrition 2020-02, Vol.59 (1), p.81-91
Main Authors: Teixeira, Juliana Araujo, Steluti, Josiane, Gorgulho, Bartira Mendes, Carioca, Antonio Augusto Ferreira, Alencar, Gizelton Pereira, Fisberg, Regina Mara, Marchioni, Dirce Maria
Format: Article
Language:English
Subjects:
Adolescent
Adult
Chemistry
Chemistry and Materials Science
Cross-Sectional Studies
Diet - methods
Diet - statistics & numerical data
Docosahexaenoic acid
Docosahexaenoic Acids - blood
Factor analysis
Female
Folic acid
Folic Acid - blood
Homocysteine
Homocysteine - blood
Humans
Life Style
Male
Methylenetetrahydrofolate reductase
Middle Aged
Minority & ethnic groups
Models, Theoretical
Nutrients
Nutrition
Original Contribution
Polymorphism
Sociodemographics
Socioeconomic Factors
Structural equation modeling
Surveys and Questionnaires
Vitamin B
Vitamin B 12 - blood
Vitamin B12
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose A structural equation model (SEM) was used to test multiple and simultaneous relationships between socio-demographic factors, dietary patterns, biochemical levels of folate, vitamin B12, docosahexaenoic acid (DHA), and its effects on homocysteine (Hcy) level. Methods Socio-demographic and lifestyle characteristics, blood sample, anthropometric measurements, and a food-frequency questionnaire (FFQ) were obtained from 281 individuals of ISA-Capital study (Sao Paulo, Brazil). The dietary patterns (DP) were estimated using factor analysis with principal component’s estimation based on the frequency of daily intake derived from the 38-item FFQ. The SEM considered a theoretical model where the DP were expected to be directly associated with Hcy level, and indirectly via biochemical levels of folate, vitamin B12, and DHA. The variables sex, age, ethnicity, and MTHFR C677T polymorphism were included in the model. Results The Prudent DP (− 0.12, p  = 0.04) had a negative effect, while MTHFR C677T polymorphism (0.16, p  = 0.01), age (0.22, p  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-018-1886-8