Fatty acid synthase, Her2/neu, and E2F1 as prognostic markers of progression in non-muscle invasive bladder cancer

Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease which has an unpredictable risk of progression to muscle-invasive bladder cancer (MIBC). The selection of patients who may benefit from early radical intervention is a challenge. To define the useful prognostic markers for progres...

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Bibliographic Details
Published in:Annals of diagnostic pathology 2019-04, Vol.39, p.42-52
Main Authors: Abdelrahman, Aziza E., Rashed, Hayam E., Elkady, Ehab, Elsebai, Eman A., El-Azony, Ahmed, Matar, Ihab
Format: Article
Language:English
Subjects:
E2F1
FASN
Her2/neu
Immunohistochemistry
Non-muscle-invasive bladder cancer
Prognostic markers
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Summary:Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease which has an unpredictable risk of progression to muscle-invasive bladder cancer (MIBC). The selection of patients who may benefit from early radical intervention is a challenge. To define the useful prognostic markers for progression, we analyzed the immunohistochemical expression of fatty acid synthase (FASN), Her2/neu, and E2F1 in 60 cases of NMIBC who underwent TURBT and adjuvant intravesical bacillus-Calmette-Guérin (BCG). Their predicting role for tumor recurrence, progression, recurrence-free survival (RFS) and progression-free survival (PFS) was analyzed. High FASN expression was observed in 56.7% (34/60) of NMIBC cases, and FASN expression was significantly associated with the tumor size, grade, and tumor stage (p = 0.003, p 
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2019.01.002