Hematopoietic Progenitor Cell Mobilization for Autologous Stem Cell Transplantation in Multiple Myeloma in Contemporary Era

Successful stem cell mobilization and adequate harvesting of hematopoietic progenitor cells (HPCs) is necessary for patients with multiple myeloma (MM) undergoing high-dose chemotherapy and autologous stem cell transplantation (ASCT). Several advances have increased the efficiency and yield of HPC c...

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Bibliographic Details
Published in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2019-04, Vol.19 (4), p.200-205
Main Authors: Arora, Satyam, Majhail, Navneet S., Liu, Hien
Format: Article
Language:English
Subjects:
Antigens, CD34 - metabolism
CD34
G-CSF
Granulocyte Colony-Stimulating Factor - pharmacology
Hematopoietic Stem Cell Mobilization - trends
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - drug effects
Hematopoietic Stem Cells - metabolism
Heterocyclic Compounds - pharmacology
HPC mobilization
Humans
Mobilization
Multiple Myeloma - therapy
Plerixafor
Risk Factors
Stem Cell Niche
Transplantation, Autologous
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Summary:Successful stem cell mobilization and adequate harvesting of hematopoietic progenitor cells (HPCs) is necessary for patients with multiple myeloma (MM) undergoing high-dose chemotherapy and autologous stem cell transplantation (ASCT). Several advances have increased the efficiency and yield of HPC collection methods, and sufficient CD34+ cell collection can be expected for most patients with MM considered to be ASCT candidates. However, in some patients, HPCs will fail to mobilize and an adequate number of CD34+ cells will not be collected. In our review, we have discussed the various strategies available for mobilizing HPCs in patients with MM and the evolution of these strategies over time. We have also discussed the concept of mobilization failure, the factors predictive of poor mobilization, and the potential mobilization regimens for such patients.
ISSN:2152-2650
2152-2669
DOI:10.1016/j.clml.2018.12.010