Long noncoding RNAs: from genomic junk to rising stars in the early detection of cancer

Despite having been underappreciated in favor of their protein-coding counterparts for a long time, long noncoding RNAs (lncRNAs) have emerged as functional molecules, which defy the central dogma of molecular biology, with clear implications in cancer. Altered expression levels of some of these lar...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2019-07, Vol.411 (19), p.4265-4275
Main Authors: Miranda-Castro, Rebeca, de-los-Santos-Álvarez, Noemí, Lobo-Castañón, María Jesús
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Biomarkers
Body fluids
Cancer
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Clinical medicine
Diagnosis
Electrochemistry
Food Science
Genetic aspects
Laboratory Medicine
Molecular biology
Monitoring/Environmental Analysis
Nucleic acids
Proteins
Trends
Young Investigators in (Bio-)Analytical Chemistry
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Summary:Despite having been underappreciated in favor of their protein-coding counterparts for a long time, long noncoding RNAs (lncRNAs) have emerged as functional molecules, which defy the central dogma of molecular biology, with clear implications in cancer. Altered expression levels of some of these large transcripts in human body fluids have been related to different cancer conditions that turns them into potential noninvasive cancer biomarkers. In this review, a brief discussion about the importance and current challenges in the determination of lncRNAs associated to cancer is provided. Different electrochemical nucleic acid-based strategies for lncRNAs detection are critically described. Future perspectives and remaining challenges for the practical implementation of these methodologies in clinical medicine are also discussed.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-019-01607-6