Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans

Curtachalasins C–E (1–3), which have an unprecedent bridged 6/6/6/6 ring system, were identified from the endophytic fungus Xylaria cf. curta. Residual dipolar coupling analyses associating with density functional theory calculations were utilized to determine the relative configuration of noncrysta...

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Published in:Organic letters 2019-02, Vol.21 (4), p.1108-1111
Main Authors: Wang, Wen-Xuan, Lei, Xinxiang, Ai, Hong-Lian, Bai, Xue, Li, Jing, He, Juan, Li, Zheng-Hui, Zheng, Yong-Sheng, Feng, Tao, Liu, Ji-Kai
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Candida albicans - drug effects
Crystallography, X-Ray
Cytochalasins - chemistry
Cytochalasins - isolation & purification
Cytochalasins - pharmacology
Drug Resistance, Fungal - drug effects
Fluconazole - pharmacology
Microbial Sensitivity Tests
Models, Molecular
Molecular Conformation
Xylariales - chemistry
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cited_by cdi_FETCH-LOGICAL-a345t-eb6445cac3bcda83e220e0880f18db4a9e85bb7bf7fcfc83c031332863a64f793
cites cdi_FETCH-LOGICAL-a345t-eb6445cac3bcda83e220e0880f18db4a9e85bb7bf7fcfc83c031332863a64f793
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container_issue 4
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container_title Organic letters
container_volume 21
creator Wang, Wen-Xuan
Lei, Xinxiang
Ai, Hong-Lian
Bai, Xue
Li, Jing
He, Juan
Li, Zheng-Hui
Zheng, Yong-Sheng
Feng, Tao
Liu, Ji-Kai
description Curtachalasins C–E (1–3), which have an unprecedent bridged 6/6/6/6 ring system, were identified from the endophytic fungus Xylaria cf. curta. Residual dipolar coupling analyses associating with density functional theory calculations were utilized to determine the relative configuration of noncrystallizable compound 2. The absolute configurations of 1–3 were determined by X-ray diffraction and electronic circular dichroism calculations. Remarkably, curtachalasin C (1) showed significant resistance reversal activity against fluconazole-resistant Candida albicans.
doi_str_mv 10.1021/acs.orglett.9b00015
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Candida albicans - drug effects
Crystallography, X-Ray
Cytochalasins - chemistry
Cytochalasins - isolation & purification
Cytochalasins - pharmacology
Drug Resistance, Fungal - drug effects
Fluconazole - pharmacology
Microbial Sensitivity Tests
Models, Molecular
Molecular Conformation
Xylariales - chemistry
title Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans
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