Identification of G‐nerve agents at picogram levels from complex organic samples containing hydrocarbon interferences by aqueous extraction, followed by derivatization and liquid chromatography‐mass spectrometry analysis

The chromatograms obtained from the gas chromatography‐electron ionization mass spectrometric (GC‐EI‐MS) analysis of extracts containing G‐nerve agents in the presence of diesel, gasoline, etc., are dominated by hydrocarbon backgrounds that “mask” the G‐nerve agents, leading to severe difficulties i...

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Bibliographic Details
Published in:Journal of mass spectrometry. 2019-03, Vol.54 (3), p.274-280
Main Authors: Weissberg, Avi, Elgarisi, Maor, Madmon, Moran, Shifrovich, Avital, Blanca, Merav, Dagan, Shai
Format: Article
Language:English
Subjects:
Analysis
aqueous extraction
Biological & chemical weapons
Chromatography
derivatization
Gas chromatography
Gasoline
G‐type nerve agents
hydrocarbon backgrounds
Hydrocarbons
Identification
Ionization
LC–MS/MS
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Nerve agents
Nerves
Phenols
Solvent extraction
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Summary:The chromatograms obtained from the gas chromatography‐electron ionization mass spectrometric (GC‐EI‐MS) analysis of extracts containing G‐nerve agents in the presence of diesel, gasoline, etc., are dominated by hydrocarbon backgrounds that “mask” the G‐nerve agents, leading to severe difficulties in identification. This paper presents a practical solution for this challenge by transferring the G‐nerve agents from the organic phase into the aqueous phase using liquid‐liquid extraction (LLE), followed by derivatization with 2‐[(dimethylamino)methyl]phenol (2‐DMAMP), allowing ultrasensitive LC‐ESI‐MS/MS analysis of the G‐derivatives. The proposed approach enables rapid identification of trace amounts of G‐nerve agents with limits of identification (LOIs) at the pg/mL scale.
ISSN:1076-5174
1096-9888
DOI:10.1002/jms.4332