Repression of melanoma tumor in vitro and in vivo by photothermal effect of carbon xerogel nanoparticles

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-04, Vol.176, p.449-455
• Main Authors: Gorgizadeh, M., Azarpira, N., Dehdari Veis, R., Sattarahmady, N.
• Format: Article
• Language: English
• Subjects: Animals; Cancer; Carbon - chemistry; Carbon nanostructure; Cell Line, Tumor; Cell Survival; Diode laser; Gels - chemistry; Hyperthermia, Induced; Male; Melanins - metabolism; Melanoma - pathology; Melanoma - therapy; Mice, Inbred BALB C; Nanomedicine; Nanoparticles - chemistry; Particle Size; Phototherapy; Photothermal therapy; Temperature; Tumor Burden
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2019.01.032

[Display omitted] •CX-NPs were synthesized and characterized by electron microscopy.•Temperature increment of CX-NPs under 808-nm laser light was determined.•C540 (B16/F10) cell toxicity of CX-NPs was evaluated.•CX-NPs photothermally inhibited tumor growth. Nanosized carbonaceous materials are favorable in biomedicine applications including photothermal therapy (PTT) of cancer. Since conventional strategies of cancer treatment have not responded to this serious disease, development of efficient alternative and promising strategies is highly desirable. In this study, carbon xerogel nanoparticles (CX-NPs) were synthesized as a novel photothermal nanomaterial and activated upon laser light of 808-nm wavelength for cancer phototherapy application. The synthesized CX-NPs had a spherical shape with a size of about 16 nm that showed nice photothermal conversion ability. Upon light irradiation with a power density of 1.0 W cm−2 for 15 min, a temperature increment occurred. A concentration-dependent cytotoxicity was also obtained for CX-NPs toward the C540 (B16/F10) cell line upon light irradiation, while CX-NPs presented biocompatibility in the mice model in dark. Photothermal property of CX-NPs efficiently led to reduction in the cell viability. A low-dose of CX-NPs was also applied in PTT of a melanoma tumor-bearing animal model. Based on tumor histopathological evaluations and volume change measurements in mice, a very good control of tumor situations after PTT by CX-NPs was attained. The findings revealed that CX-NPs is a good and novel photoabsorber for PTT of cancer.