Zika Virus in Peridomestic Neotropical Primates, Northeast Brazil

Zika virus (ZIKV) is a mosquito-borne viral disease associated with fetal microcephaly and other central nervous system (CNS) symptomatology. It was first identified in a Rhesus macaque in Uganda in 1947 and later in humans (Zika fever). In 2015, ZIKV was notified in Northeast Brazil where it was as...

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Bibliographic Details
Published in:EcoHealth 2019-03, Vol.16 (1), p.61-69
Main Authors: Favoretto, Silvana R., Araujo, Danielle B., Duarte, Naylê F. H., Oliveira, Danielle B. L., da Crus, Nathalia G., Mesquita, Flavio, Leal, Fabyano, Machado, Rafael R. G., Gaio, Fernanda, Oliveira, Walber F., Zanotto, Paolo M. A., Durigon, Edison L.
Format: Article
Language:English
Subjects:
Animal behavior
Animal Ecology
Animals
Antibodies
Aquatic insects
Brazil - epidemiology
Central nervous system
Dolphins & porpoises
Ecosystems
Environmental Health
Epidemics
Fetuses
Fever
Macaca mulatta
Medicine
Medicine & Public Health
Microbiology
Microencephaly
Monkeys
Original Contribution
Polymerase Chain Reaction
Primates
Public Health
RNA, Viral
Vector-borne diseases
Viral diseases
Viral Plaque Assay
Viruses
Water and Health
Zika virus
Zika Virus Infection - veterinary
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Summary:Zika virus (ZIKV) is a mosquito-borne viral disease associated with fetal microcephaly and other central nervous system (CNS) symptomatology. It was first identified in a Rhesus macaque in Uganda in 1947 and later in humans (Zika fever). In 2015, ZIKV was notified in Northeast Brazil where it was associated with CNS alterations and with rapid epidemic spread. Considering that ZIKV infects Old World monkeys, the aim of this study was to follow its potential in neotropical primates. Here, we show the detection of ZIKV in marmosets and capuchin monkeys captured in Ceara state, Northeast Brazil. Nine (9/132) samples were positive by quantitative RT-PCR assay. Neutralizing antibodies in primates for ZIKV were also detected by PRNT. The ZIKV-positive samples were obtained from peridomestic animals captured in proximity to humans in areas with reports of ZIKV-associated microcephaly cases during the epidemic period. These results reiterate the molecular evidence of ZIKV infection in neotropical primates, and the temporal detection suggests that detection in primates occurred during the epidemic period in humans. However, a continuous surveillance is necessary to exclude the possibility of virus circulation and transmission in wild environments.
ISSN:1612-9202
1612-9210
DOI:10.1007/s10393-019-01394-7