Pulmonary Microcirculation in Experimental Model of Pulmonary Thromboembolism under Conditions of α-Adrenoceptor Blockade

Changes in the pulmonary microcirculation in isolated perfused rabbit lungs during modeling of pulmonary thromboembolism were studied in control animals and against the background of α-adrenoceptors blockade with phentolamine. Intravenous injection of emboli to control animals was followed by an inc...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-01, Vol.166 (3), p.313-316
Main Authors: Evlakhov, V. I., Poyassov, I. Z., Ovsyannikov, V. I.
Format: Article
Language:English
Subjects:
Adrenergic receptors
Biomedical and Life Sciences
Biomedicine
Cell Biology
Filtration
Internal Medicine
Intravenous administration
Laboratory Medicine
Lungs
Pathology
Phentolamine
Pressure
Pulmonary arteries
Pulmonary artery
Thromboembolism
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Summary:Changes in the pulmonary microcirculation in isolated perfused rabbit lungs during modeling of pulmonary thromboembolism were studied in control animals and against the background of α-adrenoceptors blockade with phentolamine. Intravenous injection of emboli to control animals was followed by an increase in pressure in the pulmonary artery, mean capillary hydrostatic pressure, capillary filtration coefficient, pulmonary vascular resistance, as well as precapillary and postcapillary resistances. Against the background of α-adrenoceptor blockade, the increase in most parameters was less pronounced than in control animals, while capillary filtration coefficient increased more drastically. Thus, adrenergic mechanisms are involved in the constrictor reactions of both arterial and venous pulmonary vessels under conditions of pulmonary thromboembolism.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04340-3