Visualizing telomerase activity for tumour identification by hybridization-triggered ratiometric fluorescence

Telomerase is repressed stringently in normal cells but highly activated in tumours to maintain their uncontrollable growth. We report a ratiometric fluorescence strategy for visualising telomerase activity for tumour identification. Using our strategy, tumour cells and tissues can be differentiated...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-02, Vol.55 (14), p.2035-2038
Main Authors: Zheng, Manli, Zhang, Ruilong, Tian, Xiaohe, Liu, Zhengjie, Zhang, Zhongping
Format: Article
Language:English
Subjects:
Fluorescence
Telomerase
Tumors
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Summary:Telomerase is repressed stringently in normal cells but highly activated in tumours to maintain their uncontrollable growth. We report a ratiometric fluorescence strategy for visualising telomerase activity for tumour identification. Using our strategy, tumour cells and tissues can be differentiated from normal cells and tissues by the naked eye.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc09257e