Oat bran, but not its isolated bioactive β-glucans or polyphenols, have a bifidogenic effect in an in vitro fermentation model of the gut microbiota

Wholegrain oats are known to modulate the human gut microbiota and have prebiotic properties (increase the growth of some health-promoting bacterial genera within the colon). Research to date mainly attributes these effects to the fibre content; however, oat is also a rich dietary source of polyphen...

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Bibliographic Details
Published in:British journal of nutrition 2019-03, Vol.121 (5), p.549-559
Main Authors: Kristek, Angelika, Wiese, Maria, Heuer, Patrizia, Kosik, Ondrej, Schär, Manuel Y., Soycan, Gulten, Alsharif, Sarah, Kuhnle, Gunter G. C., Walton, Gemma, Spencer, Jeremy P. E.
Format: Article
Language:English
Subjects:
Abundance
Acetic acid
Acetic Acid - metabolism
Avena - chemistry
Bacteroidetes
Bacteroidetes - drug effects
beta-Glucans - pharmacology
Bifidobacterium - drug effects
Biological activity
Carbohydrates
Cholesterol
Colon
Dietary fiber
Dietary supplements
Feces - microbiology
Fermentation
Fermentation - drug effects
Food
Food matrix
Gastrointestinal Microbiome - drug effects
Gene amplification
Gene expression
Gene sequencing
Glucan
Glucans
Health promotion
Human and Clinical Nutrition
Humans
Intestinal microflora
Laboratories
Metabolism
Metabolites
Microbiota
Molecular weight
Oat bran
Oats
Polyphenols
Polyphenols - pharmacology
Prebiotics
Propionates - metabolism
Propionic acid
Proteobacteria - drug effects
Relative abundance
Ribonucleic acid
RNA
Small intestine
Whole Grains
β-Glucan
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Summary:Wholegrain oats are known to modulate the human gut microbiota and have prebiotic properties (increase the growth of some health-promoting bacterial genera within the colon). Research to date mainly attributes these effects to the fibre content; however, oat is also a rich dietary source of polyphenols, which may contribute to the positive modulation of gut microbiota. In vitro anaerobic batch-culture experiments were performed over 24 h to evaluate the impact of two different doses (1 and 3 % (w/v)) of oat bran, matched concentrations of β-glucan extract or polyphenol mix, on the human faecal microbiota composition using 16S RNA gene sequencing and SCFA analysis. Supplementation with oats increased the abundance of Proteobacteria (P
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114518003501