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Cutaneous involvement as the first manifestation of T‐lymphoblastic lymphoma and review of the literature

Lymphoblastic lymphomas (LBLs) are uncommon malignant neoplasms derived from immature T‐ or B‐lymphoid progenitor cells. Although cutaneous involvement may reach 33% in B‐LBL, only 12 cutaneous cases of T‐LBL have been published. We report the case of a 49‐year‐old woman with 2‐month history of eryt...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2019-05, Vol.46 (5), p.372-375
Main Authors: Montes‐Torres, Andrea, Llamas‐Velasco, Mar, Capusan, Tania M., Aguado, Beatriz, Adrados, Magdalena
Format: Article
Language:English
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Summary:Lymphoblastic lymphomas (LBLs) are uncommon malignant neoplasms derived from immature T‐ or B‐lymphoid progenitor cells. Although cutaneous involvement may reach 33% in B‐LBL, only 12 cutaneous cases of T‐LBL have been published. We report the case of a 49‐year‐old woman with 2‐month history of erythematous‐violaceous plaques in the sternal region and breasts. Histopathologic examination showed a dense monomorphus infiltrate in dermis and positive immunostainings for CD3, CD99 and terminal deoxynucleotidyl transferase, thus indicating T‐LBL. Staging work‐up only revealed a mediastinal mass at diagnosis. After a 51‐month follow‐up and different treatment regimens, the patient remains alive although she has presented four relapses, all of them extramedullary.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.13431