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A comparative study of white matter volume between postoperative female-to-male transsexuals and healthy female
Cross-sex hormones in female-to-male (FtM) transsexuals play a crucial role in brain plasticity. Morphological study associated with white matter (WM) volume in postoperative FtM transsexuals receiving cross-sex hormones has not been published yet. This study was performed to discriminate the region...
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| Published in: | International journal of impotence research 2019-11, Vol.31 (6), p.432-438 |
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| cited_by | cdi_FETCH-LOGICAL-c470t-8da87611fc1e3f4e63fa1071cae547e21ef617ded82b661a86ef4f89684cd8173 |
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| cites | cdi_FETCH-LOGICAL-c470t-8da87611fc1e3f4e63fa1071cae547e21ef617ded82b661a86ef4f89684cd8173 |
| container_end_page | 438 |
| container_issue | 6 |
| container_start_page | 432 |
| container_title | International journal of impotence research |
| container_volume | 31 |
| creator | Kim, Gwang-Won Kim, Yun-Hyeon Park, Kwangsung Jeong, Gwang-Woo |
| description | Cross-sex hormones in female-to-male (FtM) transsexuals play a crucial role in brain plasticity. Morphological study associated with white matter (WM) volume in postoperative FtM transsexuals receiving cross-sex hormones has not been published yet. This study was performed to discriminate the regional WM volume differences between postoperative FtM transsexuals and female controls using voxel-based morphometry (VBM) and further to assess the correlations between regional volume variations and cross-sex hormones. WM volume was assessed in 12 postoperative FtM transsexuals receiving cross-sex hormones with 16 age-matched female controls. WM volume was processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Serum sex hormones, including estriol, free testosterone (free-T), estradiol, follicle-stimulating hormone, and luteinizing hormone were measured. Postoperative FtM transsexuals showed significantly (
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| doi_str_mv | 10.1038/s41443-019-0111-5 |
| format | article |
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p
< 0.05) larger WM volumes in the inferior parietal lobule, postcentral gyrus, and middle temporal gyrus compared with female controls. However, there were no brain areas with larger WM volume in female controls compared with FtM transsexuals. WM volumes of the inferior parietal lobule and middle temporal gyrus in FtM transsexuals were positively correlated with the levels of free-T. This study revealed WM volume change and its correlation with free-T level in postoperative FtM transsexuals. These findings will improve our understanding of the morphometric changes in FtM transsexuals under cross-sex hormone therapy.</description><identifier>ISSN: 0955-9930</identifier><identifier>EISSN: 1476-5489</identifier><identifier>DOI: 10.1038/s41443-019-0111-5</identifier><identifier>PMID: 30679768</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 692/308/2779/109 ; 692/700/139 ; Adult ; Algorithms ; Brain ; Brain research ; Comparative analysis ; Estradiol ; Female ; Follicle-stimulating hormone ; Glycoproteins ; Gonadal Steroid Hormones - blood ; Gonadal Steroid Hormones - therapeutic use ; Gyrus Cinguli - diagnostic imaging ; Health aspects ; Hormone replacement therapy ; Hormones ; Humans ; Luteinizing hormone ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurology ; Parietal Lobe - diagnostic imaging ; Pharmaceutical industry ; Postoperative Period ; Reproductive Medicine ; rology ; Sex Reassignment Surgery ; Software ; Temporal Lobe - diagnostic imaging ; Testosterone ; Testosterone - blood ; Transsexualism ; Transsexuals ; Urology ; White Matter - diagnostic imaging ; Women ; Womens health</subject><ispartof>International journal of impotence research, 2019-11, Vol.31 (6), p.432-438</ispartof><rights>Springer Nature Limited 2019</rights><rights>COPYRIGHT 2019 Nature Publishing Group</rights><rights>2019© Springer Nature Limited 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-8da87611fc1e3f4e63fa1071cae547e21ef617ded82b661a86ef4f89684cd8173</citedby><cites>FETCH-LOGICAL-c470t-8da87611fc1e3f4e63fa1071cae547e21ef617ded82b661a86ef4f89684cd8173</cites><orcidid>0000-0001-7148-715X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30679768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Gwang-Won</creatorcontrib><creatorcontrib>Kim, Yun-Hyeon</creatorcontrib><creatorcontrib>Park, Kwangsung</creatorcontrib><creatorcontrib>Jeong, Gwang-Woo</creatorcontrib><title>A comparative study of white matter volume between postoperative female-to-male transsexuals and healthy female</title><title>International journal of impotence research</title><addtitle>Int J Impot Res</addtitle><addtitle>Int J Impot Res</addtitle><description>Cross-sex hormones in female-to-male (FtM) transsexuals play a crucial role in brain plasticity. Morphological study associated with white matter (WM) volume in postoperative FtM transsexuals receiving cross-sex hormones has not been published yet. This study was performed to discriminate the regional WM volume differences between postoperative FtM transsexuals and female controls using voxel-based morphometry (VBM) and further to assess the correlations between regional volume variations and cross-sex hormones. WM volume was assessed in 12 postoperative FtM transsexuals receiving cross-sex hormones with 16 age-matched female controls. WM volume was processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Serum sex hormones, including estriol, free testosterone (free-T), estradiol, follicle-stimulating hormone, and luteinizing hormone were measured. Postoperative FtM transsexuals showed significantly (
p
< 0.05) larger WM volumes in the inferior parietal lobule, postcentral gyrus, and middle temporal gyrus compared with female controls. However, there were no brain areas with larger WM volume in female controls compared with FtM transsexuals. WM volumes of the inferior parietal lobule and middle temporal gyrus in FtM transsexuals were positively correlated with the levels of free-T. This study revealed WM volume change and its correlation with free-T level in postoperative FtM transsexuals. These findings will improve our understanding of the morphometric changes in FtM transsexuals under cross-sex hormone therapy.</description><subject>59/57</subject><subject>692/308/2779/109</subject><subject>692/700/139</subject><subject>Adult</subject><subject>Algorithms</subject><subject>Brain</subject><subject>Brain research</subject><subject>Comparative analysis</subject><subject>Estradiol</subject><subject>Female</subject><subject>Follicle-stimulating hormone</subject><subject>Glycoproteins</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Gonadal Steroid Hormones - therapeutic use</subject><subject>Gyrus Cinguli - diagnostic imaging</subject><subject>Health aspects</subject><subject>Hormone replacement therapy</subject><subject>Hormones</subject><subject>Humans</subject><subject>Luteinizing hormone</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parietal Lobe - diagnostic imaging</subject><subject>Pharmaceutical industry</subject><subject>Postoperative Period</subject><subject>Reproductive Medicine</subject><subject>rology</subject><subject>Sex Reassignment Surgery</subject><subject>Software</subject><subject>Temporal Lobe - diagnostic imaging</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Transsexualism</subject><subject>Transsexuals</subject><subject>Urology</subject><subject>White Matter - diagnostic imaging</subject><subject>Women</subject><subject>Womens health</subject><issn>0955-9930</issn><issn>1476-5489</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kk2LFDEQhoMo7rj6A7xIQBAvvaY66Xwch8UvWPCi55Dpruz00t0Zk_Su8-9N06PrihJCQeqpSt7KS8hLYBfAuH6XBAjBKwambICqeUQ2IJSsGqHNY7JhpmkqYzg7I89SumGMGQbyKTnjTCqjpN6QsKVtGA8uutzfIk157o40eHq37zPS0eWMkd6GYR6R7jDfIU70EFIOBzyVeBzdgFUO1RJpjm5KCX_MbkjUTR3doxvy_njinpMnvmTwxSmek28f3n-9_FRdffn4-XJ7VbVCsVzpzmklAXwLyL1Ayb0DpqB12AiFNaCXoDrsdL2TEpyW6IXXRmrRdhoUPydv176HGL7PmLId-9TiMLgJw5xsDcoIDoI3BX39F3oT5jiV19mawzIqqet76rqosP3kQ1HaLk3tVrKmVlKa5dqLf1BldTj2bZjQ9-X8QcGbPwrWWaUy7tyHKT0EYQXbGFKK6O0h9qOLRwvMLm6wqxtscYNd3GAXZa9OyubdiN3vil_fX4B6BVJJTdcY76X_v-tPb0y-gg</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Kim, Gwang-Won</creator><creator>Kim, Yun-Hyeon</creator><creator>Park, Kwangsung</creator><creator>Jeong, Gwang-Woo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7148-715X</orcidid></search><sort><creationdate>20191101</creationdate><title>A comparative study of white matter volume between postoperative female-to-male transsexuals and healthy female</title><author>Kim, Gwang-Won ; Kim, Yun-Hyeon ; Park, Kwangsung ; Jeong, Gwang-Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-8da87611fc1e3f4e63fa1071cae547e21ef617ded82b661a86ef4f89684cd8173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>59/57</topic><topic>692/308/2779/109</topic><topic>692/700/139</topic><topic>Adult</topic><topic>Algorithms</topic><topic>Brain</topic><topic>Brain research</topic><topic>Comparative analysis</topic><topic>Estradiol</topic><topic>Female</topic><topic>Follicle-stimulating hormone</topic><topic>Glycoproteins</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Gonadal Steroid Hormones - therapeutic use</topic><topic>Gyrus Cinguli - diagnostic imaging</topic><topic>Health aspects</topic><topic>Hormone replacement therapy</topic><topic>Hormones</topic><topic>Humans</topic><topic>Luteinizing hormone</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parietal Lobe - diagnostic imaging</topic><topic>Pharmaceutical industry</topic><topic>Postoperative Period</topic><topic>Reproductive Medicine</topic><topic>rology</topic><topic>Sex Reassignment Surgery</topic><topic>Software</topic><topic>Temporal Lobe - diagnostic imaging</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Transsexualism</topic><topic>Transsexuals</topic><topic>Urology</topic><topic>White Matter - diagnostic imaging</topic><topic>Women</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Gwang-Won</creatorcontrib><creatorcontrib>Kim, Yun-Hyeon</creatorcontrib><creatorcontrib>Park, Kwangsung</creatorcontrib><creatorcontrib>Jeong, Gwang-Woo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of impotence research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Gwang-Won</au><au>Kim, Yun-Hyeon</au><au>Park, Kwangsung</au><au>Jeong, Gwang-Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of white matter volume between postoperative female-to-male transsexuals and healthy female</atitle><jtitle>International journal of impotence research</jtitle><stitle>Int J Impot Res</stitle><addtitle>Int J Impot Res</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>31</volume><issue>6</issue><spage>432</spage><epage>438</epage><pages>432-438</pages><issn>0955-9930</issn><eissn>1476-5489</eissn><abstract>Cross-sex hormones in female-to-male (FtM) transsexuals play a crucial role in brain plasticity. Morphological study associated with white matter (WM) volume in postoperative FtM transsexuals receiving cross-sex hormones has not been published yet. This study was performed to discriminate the regional WM volume differences between postoperative FtM transsexuals and female controls using voxel-based morphometry (VBM) and further to assess the correlations between regional volume variations and cross-sex hormones. WM volume was assessed in 12 postoperative FtM transsexuals receiving cross-sex hormones with 16 age-matched female controls. WM volume was processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Serum sex hormones, including estriol, free testosterone (free-T), estradiol, follicle-stimulating hormone, and luteinizing hormone were measured. Postoperative FtM transsexuals showed significantly (
p
< 0.05) larger WM volumes in the inferior parietal lobule, postcentral gyrus, and middle temporal gyrus compared with female controls. However, there were no brain areas with larger WM volume in female controls compared with FtM transsexuals. WM volumes of the inferior parietal lobule and middle temporal gyrus in FtM transsexuals were positively correlated with the levels of free-T. This study revealed WM volume change and its correlation with free-T level in postoperative FtM transsexuals. These findings will improve our understanding of the morphometric changes in FtM transsexuals under cross-sex hormone therapy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30679768</pmid><doi>10.1038/s41443-019-0111-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7148-715X</orcidid></addata></record> |
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| ispartof | International journal of impotence research, 2019-11, Vol.31 (6), p.432-438 |
| issn | 0955-9930 1476-5489 |
| language | eng |
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| source | Springer Link; Alma/SFX Local Collection |
| subjects | 59/57 692/308/2779/109 692/700/139 Adult Algorithms Brain Brain research Comparative analysis Estradiol Female Follicle-stimulating hormone Glycoproteins Gonadal Steroid Hormones - blood Gonadal Steroid Hormones - therapeutic use Gyrus Cinguli - diagnostic imaging Health aspects Hormone replacement therapy Hormones Humans Luteinizing hormone Magnetic Resonance Imaging Male Medicine Medicine & Public Health Middle Aged Neurology Parietal Lobe - diagnostic imaging Pharmaceutical industry Postoperative Period Reproductive Medicine rology Sex Reassignment Surgery Software Temporal Lobe - diagnostic imaging Testosterone Testosterone - blood Transsexualism Transsexuals Urology White Matter - diagnostic imaging Women Womens health |
| title | A comparative study of white matter volume between postoperative female-to-male transsexuals and healthy female |
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