Cyanidin inhibits EMT induced by oxaliplatin via targeting the PDK1-PI3K/Akt signaling pathway

• Published in: Food & function 2019-02, Vol.10 (2), p.592-601
• Main Authors: Li, Xiang, Zhang, Ze-Sheng, Zhang, Xiao-Han, Yang, Sheng-Nan, Liu, Dong, Diao, Cui-Ru, Wang, Hao, Zheng, Fu-Ping
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Anthocyanins; Anticancer properties; Antitumor activity; Biomarkers; Cancer; Drug resistance; Kinases; Metastases; Oxaliplatin; Platinum; Protein kinase; Proteins; Signal transduction; Signaling
• ISSN: 2042-6496; 2042-650X
• DOI: 10.1039/c8fo01611a

Anthocyanins have been shown to exhibit antitumor activity in several cancers in vitro and in vivo. Oxaliplatin is widely used as an anti-cancer drug. However, a large proportion of patients receiving platinum-based anti-cancer drug treatments will relapse because of metastasis and drug resistance. The aim of this study is to discover an effective anthocyanin that possesses the combinational anti-metastatic effects of oxaliplatin. Our results showed that cyanidin, one of the main constituents of anthocyanins, widely found in black rice, black bean, Hawthorn and other foods, could reverse drug resistance and enhance the effects of oxaliplatin on hepatic cellular cancer (HCC). Cyanidin inhibited migration and reversed EMT biomarker changes induced by low dose OXA. Moreover, 3-phosphoinositide-dependent protein kinase 1 (PDK1) can be considered a potential target and cyanidin significantly increased OXA sensitivity and inhibited the EMT induced by OXA via PI3K/Akt signaling in HCC.